Generalized lipodystrophy (lipoatrophic diabetes): Evidence for abnormal pituitary function

Human Type 2 Diabetes Morphological Evidence for Abnormal -Cell Function

The exact nature of the -cell defect in type 2 diabetic patients is still unclear. -Cell mass reduction has been reported but remains controversial. A preliminary study of a large series of patients has demonstrated that in most, the -cell defect is not related to a decreased -cell mass. Amyloid deposits are observed in the islets of some type 2 diabetic patients but also in normoglycemic subje...

Generalized Lipodystrophy.

Lipoatrophic diabetes. Report of a case.

The female patient initially showed the acquired type of total lipoatrophy at about 8 years of age. At 12 years of age, the onset of diabetes mellitus was speculated from advanced pyodermia and dedentition. At 29 years of age, glucosuria was found, and she developed proteinuria, ascites, and pretibial edema. The physical examination revealed: hepatosplenomegaly, complete absence of subcutanous ...

Congenital generalized lipodystrophy.

Clinical features of congenital generalized lipodystrophy, a rare disorder, first described by Zeigler include loss of subcutaneous fat, hepatomegaly, increased bone growth, hyperlipaemia and, later, diabetes. The inheritance is probably autosomal recessive. Generalized lipodystrophy may involve the diencephalon. A probable defect in the hypothalamus may lead to increased levels of hypothalamic...

Hypothesis: hypothalamic dysfunction and lipoatrophic diabetes.

The concept that the hypothalamus controls anterior pituitary function via the production of neurohormonal releasing and inhibitory factors (RFs and IFs, respectively) is well documented (1). There is a growing body of evidence relating endocrine disorders to hypothalamic dysfunction that has resulted in a wide variety of endocrine and metabolic imbalances (2, 3). In an effort to explain the pa...